Bayesian method for filtering out mRNA turnover rate bias from siRNA knockdown measurements

Abstract siRNA performance prediction calculations for a given siRNA may be divided into two broad categories: functions of the siRNA’s sequence, hereafter referred to as “intrinsic” properties of the siRNA, and functions of the target mRNA, hereafter referred to as “extrinsic” properties of the siRNA. When training a statistical or machine learning model to select […]

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HRC Corporate Equality Index correlates with Fortune’s 50 most admired companies

The Human Right’s Campaign, one of America’s largest civil rights groups, scores companies in its yearly Corporate Equality Index (CEI) according to their treatment of lesbian, gay, bisexual, and transgender employees [1]. The companies automatically evaluated are the Fortune 1000 and American Lawyer’s top 200. Additionally, any sufficiently large private sector organization can request inclusion […]

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fast genomic coordinate comparison using PostgreSQL’s geometric operators

PostgreSQL provides operators for comparing geometric data types, for example for computing whether two boxes overlap or whether one box contains another. Such operators are quick compared to similar calculations implemented using normal comparison operators, which I’ll demonstrate below. Here I show use of such geometric data types and operators for determining whether one segment […]

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