Bayesian method for filtering out mRNA turnover rate bias from siRNA knockdown measurements

Abstract siRNA performance prediction calculations for a given siRNA may be divided into two broad categories: functions of the siRNA’s sequence, hereafter referred to as “intrinsic” properties of the siRNA, and functions of the target mRNA, hereafter referred to as “extrinsic” properties of the siRNA. When training a statistical or machine learning model to select […]

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21504 to 1 odds the sun will rise tomorrow: an illustration of Bayesian reasoning

The following preposterous case illustrates the Bayesian worldview: Prior estimate If you ask a mathematically-gifted newborn for the probability that the sun will rise tomorrow, they might reply: “The probability that the sun will rise tomorrow follows a beta distribution with parameters a = b = 2.” Since the mean of the above distribution is […]

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