Bayesian method for filtering out mRNA turnover rate bias from siRNA knockdown measurements

Abstract siRNA performance prediction calculations for a given siRNA may be divided into two broad categories: functions of the siRNA’s sequence, hereafter referred to as “intrinsic” properties of the siRNA, and functions of the target mRNA, hereafter referred to as “extrinsic” properties of the siRNA. When training a statistical or machine learning model to select […]

GNU Octave: a free, open source MATLAB-like language for numerical computing

I tend to use Python with the Numpy, SciPy, and Matplotlib stack whenever I have to do scientific computing. For statistical computing I use R whenever this Python stack does not provide the necessary features. However, I want to draw readers’ attention to another tool for free, open-source numerical computing: GNU Octave (hereafter called “Octave”), […]