Bayesian method for filtering out mRNA turnover rate bias from siRNA knockdown measurements

Abstract siRNA performance prediction calculations for a given siRNA may be divided into two broad categories: functions of the siRNA’s sequence, hereafter referred to as “intrinsic” properties of the siRNA, and functions of the target mRNA, hereafter referred to as “extrinsic” properties of the siRNA. When training a statistical or machine learning model to select […]

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HRC Corporate Equality Index correlates with Fortune’s 50 most admired companies

The Human Right’s Campaign, one of America’s largest civil rights groups, scores companies in its yearly Corporate Equality Index (CEI) according to their treatment of lesbian, gay, bisexual, and transgender employees [1]. The companies automatically evaluated are the Fortune 1000 and American Lawyer’s top 200. Additionally, any sufficiently large private sector organization can request inclusion […]

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reporting negative results

Two of my recent posts have reported negative results, meaning that no meaningful effects were found during the investigations. Had these investigations been framed as hypothesis tests, we would have failed to reject the null hypotheses. Sounds boring. However there are good reasons to report these results. The first is that negative results still generate […]

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fuzzy logic toolkit in C++

I recently came across some old C++ code I wrote about 10 years ago to assist fuzzy logic reasoning. This program is now posted on GitHub at https://github.com/badassdatascience/fuzzy-logic-toolkit and is described below. An example of the tool in action (with code) follows the description. Fuzzy Logic Suppose we have a numerical value for distance to […]

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