RNAfold and sequence length

I’ve been looking for a way to compare RNAfold [1] dG results for two RNA sequences, where the two sequences differ in length. My initial thought was to simply divide the computed dG’s by sequence length (i.e., normalize by sequence length) and then compare the results. The analysis presented below shows why this won’t work. […]

Stephen Colbert teaches proper data normalization

Colbert Report devotees recently witnessed a true miracle—Stephen Colbert spoke data science: Due to the massive volume [of suggestions received], we … used computers to crunch the data. Mr. Colbert had just received approximately 53,000 e-mailed suggestions from his minions proposing social issues for the newly formed Colbert Super PAC to address. Financial contributions to […]